Bioware基因槍 國際期刊論文發表

Bioware基因槍 國際期刊論文發表



  1. Antigen-specific CD8+ T lymphocytes generated from a DNA vaccine control tumors through the Fas-FasL pathway. Cheng WF1, Lee CN, Chang MC, Su YN, Chen CA, Hsieh CY. Mol Ther. 2005 Nov;12(5):960-8.
  2. Characterization of DNA vaccines encoding the domains of calreticulin for their ability to elicit tumor-specific immunity and antiangiogenesis. Cheng WF1, Hung CF, Chen CA, Lee CN, Su YN, Chai CY, Boyd DA, Hsieh CY, Wu TC. Vaccine. 2005 May 31;23(29):3864-74
  3. DNA vaccine encoding heat shock protein 60 co-linked to HPV16 E6 and E7 tumor antigens generates more potent immunotherapeutic effects than respective E6 or E7 tumor antigens. Huang CY1, Chen CA, Lee CN, Chang MC, Su YN, Lin YC, Hsieh CY, Cheng WF. Gynecol Oncol. 2007 Dec;107(3):404-12.
  4. IL-6-encoding tumor antigen generates potent cancer immunotherapy through antigen processing and anti-apoptotic pathways. Hsieh CY1, Chen CA, Huang CY, Chang MC, Lee CN, Su YN, Cheng WF. Mol Ther. 2007 Oct;15(10):1890-7.
  5. PMMA particle-mediated DNA vaccine for cervical cancer. Lou PJ1, Cheng WF, Chung YC, Cheng CY, Chiu LH, Young TH. J Biomed Mater Res A. 2008 Mar 15;88(4):849-57.
  6. Connective tissue growth factor linked to the E7 tumor antigen generates potent antitumor immune responses mediated by an antiapoptotic mechanism. Cheng WF1, Chang MC, Sun WZ, Lee CN, Lin HW, Su YN, Hsieh CY, Chen CA. Gene Ther. 2008 Jul;15(13):1007-16.
  7. Noncarrier naked antigen-specific DNA vaccine generates potent antigen-specific immunologic responses and antitumor effects. Chen CA1, Chang MC, Sun WZ, Chen YL, Chiang YC, Hsieh CY, Chen SM, Hsiao PN, Cheng WF. Gene Ther. 2009 Jun;16(6):776-87.
  8. Metronomic chemotherapy enhances antitumor effects of cancer vaccine by depleting regulatory T lymphocytes and inhibiting tumor angiogenesis. Chen CA1, Ho CM, Chang MC, Sun WZ, Chen YL, Chiang YC, Syu MH, Hsieh CY, Cheng WF. Mol Ther. 2010 Jun;18(6):1233-43.
  9. The role of adenosine receptor and caveolae-mediated endocytosis in oligonucleotide-mediated gene transfer. Chung YC1, Cheng TY, Young TH. Biomaterials. 2011 Jul;32(19):4471-80.
  10. Immuno-modulators enhance antigen-specific immunity and anti-tumor effects of mesothelin-specific chimeric DNA vaccine through promoting DC maturation. Chen YL1, Chang MC2, Chiang YC1, Lin HW3, Sun NY3, Chen CA1, Sun WZ4, Cheng WF5. Cancer Lett. 2018 Jul 1;425:152-163.
  11. Irradiation Enhances Abscopal Anti-tumor Effects of Antigen-Specific Immunotherapy through Regulating Tumor Microenvironment. Chang MC1, Chen YL2, Lin HW3, Chiang YC2, Chang CF2, Hsieh SF2, Chen CA2, Sun WZ4, Cheng WF5. Mol Ther. 2018 Feb 7;26(2):404-419.

二、國立成功大學 & 國立中興大學(12-27)

  1. Autologous neu DNA vaccine can be as effective as xenogenic neu DNA vaccine by altering administration route. Tu CF1, Lin CC, Chen MC, Ko TM, Lin CM, Wang YC, Lai MD. Vaccine. 2007 Jan 8;25(4):719-28. Epub 2006 Aug 22.
  2. Delivery of noncarrier naked DNA vaccine into the skin by supersonic flow induces a polarized T helper type 1 immune response to cancer. Lin CC1, Yen MC, Lin CM, Huang SS, Yang HJ, Chow NH, Lai MD. J Gene Med. 2008 Jun;10(6):679-89.
  3. A novel cancer therapy by skin delivery of indoleamine 2,3-dioxygenase siRNA. Yen MC1, Lin CC, Chen YL, Huang SS, Yang HJ, Chang CP, Lei HY, Lai MD. Clin Cancer Res. 2009 Jan 15;15(2):641-9.
  4. An HDAC inhibitor enhances the antitumor activity of a CMV promoter-driven DNA vaccine. Lai MD1, Chen CS, Yang CR, Yuan SY, Tsai JJ, Tu CF, Wang CC, Yen MC, Lin CC. Cancer Gene Ther. 2009 Mar;17(3):203-11.
  5. The effects of DNA formulation and administration route on cancer therapeutic efficacy with xenogenic EGFR DNA vaccine in a lung cancer animal model. Lai MD1, Yen MC, Lin CM, Tu CF, Wang CC, Lin PS, Yang HJ, Lin CC. Genet Vaccines Ther. 2009 Jan 30;7:2.
  6. Promoting effect of Antrodia camphorata as an immunomodulating adjuvant on the antitumor efficacy of HER-2/neu DNA vaccine. Huang CH1, Chang CC, Lin CM, Wang ST, Wu MT, Li EI, Chang HC, Lin CC. Cancer Immunol Immunother. 2010 Aug;59(8):1259-72.
  7. A novel adjuvant Ling Zhi-8 enhances the efficacy of DNA cancer vaccine by activating dendritic cells. Lin CC1, Yu YL, Shih CC, Liu KJ, Ou KL, Hong LZ, Chen JD, Chu CL. Cancer Immunol Immunother. 2011 Jul;60(7):1019-27.
  8. RNA interference-mediated silencing of Foxo3 in antigen-presenting cells as a strategy for the enhancement of DNA vaccine potency. Wang ST1, Chang CC, Yen MC, Tu CF, Chu CL, Peng YT, Chen DY, Lan JL, Lin CC. Gene Ther. 2011 Apr;18(4):372-83.
  9. Skin delivery of short hairpin RNA of indoleamine 2,3 dioxygenase induces antitumor immunity against orthotopic and metastatic liver cancer. Huang TT1, Yen MC, Lin CC, Weng TY, Chen YL, Lin CM, Lai MD. Cancer Sci. 2011 Dec;102(12):2214-20.
  10. An HDAC inhibitor enhances cancer therapeutic efficiency of RNA polymerase III promoter-driven IDO shRNA. Yen MC1, Weng TY, Chen YL, Lin CC, Chen CY, Wang CY, Chao HL, Chen CS, Lai MD. Cancer Gene Ther. 2013 Jun;20(6):351-7.
  11. Biolistic DNA delivery to mice with the low pressure gene gun. Yen MC1, Lai MD. Methods Mol Biol. Chap. 14. 2013;940:169-74
  12. A novel cancer therapeutic using thrombospondin 1 in dendritic cells. Weng TY1, Huang SS2, Yen MC3, Lin CC4, Chen YL5, Lin CM6, Chen WC1, Wang CY1, Chang JY7, Lai MD8. Mol Ther. 2014 Feb;22(2):292-302.
  13. DNA vaccine elicits an efficient antitumor response by targeting the mutant Kras in a transgenic mouse lung cancer model. Weng TY1, Yen MC2, Huang CT3, Hung JJ4, Chen YL5, Chen WC1, Wang CY1, Chang JY6, Lai MD2. Gene Ther. 2014 Oct;21(10):888-96.
  14. The adjuvant effects of high-molecule-weight polysaccharides purified from Antrodia cinnamomea on dendritic cell function and DNA vaccines. Lin CC1, Pan IH2, Li YR3, Pan YG4, Lin MK5, Lu YH2, Wu HC2, Chu CL4. PLoS One. 2015 Feb 27;10(2):e0116191.
  15. Myostatin propeptide gene delivery by gene gun ameliorates muscle atrophy in a rat model of botulinum toxin-induced nerve denervation. Tsai SW1, Tung YT2, Chen HL3, Yang SH4, Liu CY5, Lu M2, Pai HJ2, Lin CC6, Chen CM7. Life Sci. 2016 Feb 1;146:15-23.
  16. Skin Delivery of Clec4a Small Hairpin RNA Elicited an Effective Antitumor Response by Enhancing CD8+ Immunity In Vivo. Weng TY1, Li CJ2, Li CY3, Hung YH4, Yen MC5, Chang YW6, Chen YH7, Chen YL8, Hsu HP9, Chang JY10, Lai MD11. Mol Ther Nucleic Acids. 2017 Dec 15;9:419-427.


  1. Mechanical stretch enhances the expression of resistin gene in cultured cardiomyocytes via tumor necrosis factor-alpha. Wang BW1, Hung HF, Chang H, Kuan P, Shyu KG. Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2305-12.
  2. Angiotensin II activates myostatin expression in cultured rat neonatal cardiomyocytes via p38 MAP kinase and myocyte enhance factor 2 pathway. Wang BW1, Chang H, Kuan P, Shyu KG. J Endocrinol. 2008 Apr;197(1):85-93.
  3. Hypoxia induces discoidin domain receptor-2 expression via the p38 pathway in vascular smooth muscle cells to increase their migration. Chen SC1, Wang BW, Wang DL, Shyu KG. Biochem Biophys Res Commun. 2008 Oct 3;374(4):662-7.
  4. The molecular regulation of GADD153 in apoptosis of cultured vascular smooth muscle cells by cyclic mechanical stretch. Cheng WP1, Hung HF, Wang BW, Shyu KG. Cardiovasc Res. 2008 Feb 1;77(3):551-9.
  5. The molecular regulation of resistin expression in cultured vascular smooth muscle cells under hypoxia. Hung HF1, Wang BW, Chang H, Shyu KG. J Hypertens. 2008 Dec;26(12):2349-60.
  6. Hyperbaric oxygen activates discoidin domain receptor 2 via tumour necrosis factor-alpha and the p38 MAPK pathway to increase vascular smooth muscle cell migration through matrix metalloproteinase 2. Shyu KG1, Wang BW, Chang H. Clin Sci (Lond). 2009 Apr;116(7):575-83.
  7. Mechanism of inhibitory effect of atorvastatin on resistin expression induced by tumor necrosis factor-alpha in macrophages. Shyu KG1, Chua SK, Wang BW, Kuan P. J Biomed Sci. 2009 May 27;16:50.
  8. Regulation of GADD153 induced by mechanical stress in cardiomyocytes. Cheng WP1, Wang BW, Shyu KG. Eur J Clin Invest. 2009 Nov;39(11):960-71.
  9. Angiotensin II and the ERK pathway mediate the induction of myocardin by hypoxia in cultured rat neonatal cardiomyocytes. Chiu CZ1, Wang BW, Chung TH, Shyu KG. Clin Sci (Lond). 2010 Jun 22;119(7):273-82.
  10. Cyclic stretch enhances the expression of toll-like receptor 4 gene in cultured cardiomyocytes via p38 MAP kinase and NF-kappaB pathway. Shyu KG1, Wang BW, Lin CM, Chang H. J Biomed Sci. 2010 Mar 5;17:15.
  11. Mechanism of the inhibitory effect of atorvastatin on endoglin expression induced by transforming growth factor-beta1 in cultured cardiac fibroblasts. Shyu KG1, Wang BW, Chen WJ, Kuan P, Hung CR. Eur J Heart Fail. 2010 Mar;12(3):219-26.
  12. Regulation of resistin by cyclic mechanical stretch in cultured rat vascular smooth muscle cells. Wang BW1, Chang H, Shyu KG. Clin Sci (Lond). 2010 Oct 26;118(3):221-30.
  13. Angiotensin II mediates urotensin II expression by hypoxia in cultured cardiac fibroblast. Shyu KG1, Wang BW, Chen WJ, Kuan P, Lin CM. Eur J Clin Invest. 2011 Jan;42(1):17-26.
  14. Tumor necrosis factor-α enhances hyperbaric oxygen-induced visfatin expression via JNK pathway in human coronary arterial endothelial cells. Wang BW1, Lin CM, Wu GJ, Shyu KG. J Biomed Sci. 2011 May 4;18:27.
  15. Mechanical stretch induces the apoptosis regulator PUMA in vascular smooth muscle cells. Cheng WP1, Wang BW, Chen SC, Chang H, Shyu KG. Cardiovasc Res. 2012 Jan 1;93(1):181-9.
  16. Regulation of PUMA induced by mechanical stress in rat cardiomyocytes. Cheng WP1, Wu GJ, Wang BW, Shyu KG. J Biomed Sci. 2012 Aug 3;19:72.
  17. Silibinin inhibits the invasion of IL-6-stimulated colon cancer cells via selective JNK/AP-1/MMP-2 modulation in vitro. Lin CM1, Chen YH, Ma HP, Wang BW, Chiu JH, Chua SK, Ong JR, Shyu KG. J Agric Food Chem. 2012 Dec 26;60(51):12451-7.
  18. Use of atorvastatin to inhibit hypoxia-induced myocardin expression. Chiu CZ1, Wang BW, Shyu KG. Eur J Clin Invest. 2012 May;42(5):564-71.
  19. Effects of cyclic stretch on the molecular regulation of myocardin in rat aortic vascular smooth muscle cells. Chiu CZ, Wang BW, Shyu KG. J Biomed Sci. 2013 Jul 15;20:50.
  20. Mechanical stretch via transforming growth factor-β1 activates microRNA208a to regulate endoglin expression in cultured rat cardiac myoblasts. Shyu KG1, Wang BW, Wu GJ, Lin CM, Chang H. Eur J Heart Fail. 2013 Jan;15(1):36-45.
  21. Mechanical stretch via transforming growth factor-β1 activates microRNA-208a to regulate hypertrophy in cultured rat cardiac myocytes. Wang BW1, Wu GJ, Cheng WP, Shyu KG. J Formos Med Assoc. 2013 Oct;112(10):635-43.
  22. Angiotensin II and the JNK pathway mediate urotensin II expression in response to hypoxia in rat cardiomyocytes. Chiu CZ1, Wang BW, Shyu KG. J Endocrinol. 2014 Jan 30;220(3):233-46.
  23. MicroRNA-208a increases myocardial fibrosis via endoglin in volume overloading heart. Wang BW1, Wu GJ2, Cheng WP3, Shyu KG4. PLoS One. 2014 Jan 2;9(1):e84188.
  24. Angiotensin II Downregulates MicroRNA-145 to Regulate Kruppel-like Factor 4 and Myocardin Expression in Human Coronary Arterial Smooth Muscle Cells under High Glucose Conditions. Shyu KG1,2, Cheng WP3, Wang BW3. Mol Med. 2015 Jul 14;21:616-25.
  25. Mechanical Stretch Induces Apoptosis Regulator TRB3 in Cultured Cardiomyocytes and Volume-Overloaded Heart. Cheng WP1, Wang BW1, Lo HM2, Shyu KG3. PLoS One. 2015 Apr 21;10(4):e0123235.
  26. MicroRNA-208a Increases Myocardial Endoglin Expression and Myocardial Fibrosis in Acute Myocardial Infarction. Shyu KG1, Wang BW2, Cheng WP2, Lo HM3. Can J Cardiol. 2015 May;31(5):679-90.
  27. Molecular regulation of the expression of leptin by hypoxia in human coronary artery smooth muscle cells. Chiu CZ1,2, Wang BW3, Shyu KG4,5. J Biomed Sci. 2015 Jan 9;22:5.
  28. Mechanical Stretch Inhibits MicroRNA499 via p53 to Regulate Calcineurin-A Expression in Rat Cardiomyocytes. Chua SK1,2,3, Wang BW2,3, Lien LM4,5, Lo HM2,3, Chiu CZ2,3, Shyu KG1,2. PLoS One. 2016 Feb 9;11(2):e0148683.
  29. Suppressive effect of epigallocatechin-3-O-gallate on endoglin molecular regulation in myocardial fibrosis in vitro and in vivo. Lin CM1,2,3, Chang H1,3, Wang BW4, Shyu KG5,6. J Cell Mol Med. 2016 Nov;20(11):2045-2055.
  30. Atorvastatin alleviates cardiomyocyte apoptosis by suppressing TRB3 induced by acute myocardial infarction and hypoxia. Cheng WP1, Lo HM2, Wang BW1, Chua SK3, Lu MJ4, Shyu KG5. J Formos Med Assoc. 2017 May;116(5):388-397.
  31. Effects of flavonoids on MicroRNA 145 regulation through Klf4 and myocardin in neointimal formation in vitro and in vivo. Lin CM1, Wang BW2, Pan CM2, Fang WJ2, Chua SK3, Hou SW4, Chang H5, Shyu KG6. J Nutr Biochem. 2018 Feb;52:27-35.
  32. MicroRNA-145 regulates disabled-2 and Wnt3a expression in cardiomyocytes under hyperglycaemia. Wang BW1, Fang WJ1, Shyu KG2. Eur J Clin Invest. 2018 Jan;48(1).


  1. Gene gun bombardment with DNA-coated gold particles is a potential alternative to hydrodynamics-based transfection for delivering genes into superficial hepatocytes. Chang ML1, Chen JC, Yeh CT, Chang MY, Liang CK, Chiu CT, Lin DY, Liaw YF. Hum Gene Ther. 2008 Apr;19(4):391-5.


  1. Tumor Necrosis Factor-Alpha and the ERK Pathway Drive Chemerin Expression in Response to Hypoxia in Cultured Human Coronary Artery Endothelial Cells. Chua SK1,2, Shyu KG2, Lin YF1,3, Lo HM2, Wang BW4, Chang H5,6, Lien LM7,8. PLoS One. 2016 Oct 28;11(10):e0165613.


  1. A low-pressure gene gun for genetic transformation of maize (Zea mays L.). Kao CY, Huang SH, Lin CM. Plant Biotechnology Reports. 2008;2(4):267-270.


  1. Effects of overexpression of a bHLH transcription factor on biomass and lipid production in Nannochloropsis salina. Kang NK1, Jeon S1, Kwon S1, Koh HG1, Shin SE1, Lee B1, Choi GG2, Yang JW1, Jeong BR1, Chang YK3. Biotechnol Biofuels. 2015 Dec 1;8:200.
  2. Heterologous overexpression of sfCherry fluorescent protein in Nannochloropsis salina. Kang NK1, Choi GG1, Kim EK2, Shin SE1, Jeon S1, Park MS3, Jeong KJ1, Jeong BR1, Chang YK3, Yang JW3, Lee B1. Biotechnol Rep (Amst). 2015 Aug 22;8:10-15.
  3. Use of conditioned medium for efficient transformation and cost-effective cultivation of Nannochloropsis salina. Kang NK1, Lee B1, Shin SE1, Jeon S1, Park MS2, Yang JW3. Bioresour Technol. 2015 Apr;181:231-7.
  4. Enhancement of biomass and lipid productivity by overexpression of a bZIP transcription factor in Nannochloropsis salina. Kwon S1, Kang NK1, Koh HG1, Shin SE1, Lee B1, Jeong BR1, Chang YK1,2. Biotechnol Bioeng. 2017 Feb;115(2):331-340
  5. Increased lipid production by heterologous expression of AtWRI1 transcription factor in Nannochloropsis salina. Kang NK1, Kim EK2, Kim YU3, Lee B1, Jeong WJ3, Jeong BR1, Chang YK1,2. Biotechnol Biofuels. 2017 Oct 10;10:231.


  1. Cloning of SjCA gene and its expression analysis on upland cottons. Kong, J., Lu, X., Zhao, X., Yin, Z., Wang, S., Wang, D., & Ye, W. Journal of Biomedical Engineering and Informatics. 2016;2(2):150.


  1. The Sweet Potato NAC-Domain Transcription Factor IbNAC1 Is Dynamically Coordinated by the Activator IbbHLH3 and the Repressor IbbHLH4 to Reprogram the Defense Mechanism against Wounding. Chen SP1, Kuo CH1, Lu HH1, Lo HS1, Yeh KW1. PLoS Genet. 2016 Oct 25;12(10):e1006397.


  1. Transient gene expression in the wheat leaf cells with the low-pressure gene delivery system. Mizoo N, Takumi S, Yoshida K. Kobe University. 2017.